Yearly Mega Dose Ups Risk of Falls

MELBOURNE, May 13 (UPI) — Australian researchers have linked one yearly mega dose of vitamin D — versus a placebo — to higher risk of falls and fractures.

Kerrie Sanders of the University of Melbourne and colleagues conducted a randomized trial of the use of a single yearly dose of vitamin D as a clinical intervention to counter low adherence to daily supplementation.

The researchers say 837 women randomly received the yearly dose of 500,000 International Units of vitamin D in the form of cholecalciferol. Seventy-four percent had at least 1 fall — versus the 68 percent of the 769 women who received a placebo.

The women given the annual high-dose vitamin D group experienced 15 percent more falls. They also had 26 percent more fractures — 171 fractures in the vitamin D group versus 135 in the placebo group.

“This is the first study to demonstrate increased risk of falls associated with any vitamin D intervention and the second study to demonstrate an increased fracture risk associated with annual high-dose vitamin D therapy in elderly women,” Sanders said in a statement.

Sanders and colleagues recruited 2,256 women 2003 to 2005. Participants — all age 70 or older and considered at high risk of fracture — received the cholecalciferol or placebo each year for three to five years until the study concluded in 2008.

The study is published in the Journal of the American Medical Association.

Copyright 2010 United Press International, Inc. (UPI). Any reproduction, republication, redistribution and/or modification of any UPI content is expressly prohibited without UPI’s prior written consent.

Categorized | Other
Leave a Reply

You must be logged in to post a comment.