NOTTINGHAM, England, May 14 (UPI) — The epidemic of esophageal and upper stomach cancer may be due to alcohol, smoking and obesity, researchers in Britain said.
Researchers at the University of Nottingham and Nottingham University Hospitals found that since the 1970s, the incidence of esophageal and upper stomach cancer has increased by 50 percent in men and 20 percent in women. The rate of this cancer in white men in Britain is the highest in the world, and diet and lifestyle are the key factors behind the rapid rise, the researchers said.
The researchers used molecular cancer pathology and DNA protein expression techniques on tumor samples from some 250 patients after surgery that indicated 40 percent to 50 percent of the cancer would respond to chemotherapy.
The researcher said the monitoring test during treatment allows physicians assess whether and how far the tumor is regressing during chemotherapy. The researcher also identified a promising protein marker involved in DNA repair in cancer cells that predicts resistance to chemotherapy in tumors.
The study, published in the British Journal of Cancer, said the new information could help doctors to decide whether to recommend a second course of chemotherapy after surgery.
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