ANN ARBOR, Mich., Oct. 22 (UPI) — A French-U.S. research team says a protein involved in hormone signaling is also made by blood vessel cells in cancer tumors and could be a good drug target.
Researchers say the protein showed up in 11 kinds of tumors examined but was notably absent in most healthy tissues, ScienceNews.org reported.
The discovery suggests that the protein, called a follicle stimulating hormone receptor, helps cancer gain a foothold by recruiting blood vessels to nourish the tumor.
Earlier studies had linked the protein to prostate cancer, and in the new study researchers found the receptor in every one of 773 prostate tumor samples they tested in blood vessel cells on the tumors.
The FSH receptor was absent in healthy prostate tissues from these patients, they said.
The researchers also found this pattern repeated when they looked at 10 other types of tumors obtained from 563 other patients.
“This is strong work with potential for significant clinical impact,” says Edgar Ben-Josef, a radiation oncologist at the University of Michigan in Ann Arbor who was not part of the new study. “This receptor may be a valuable target for suppression.”
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