Prostate Cancer, Less Bone Loss Linked

BALTIMORE, July 14 (UPI) — Men with high-risk prostate cancer appear to have lower bone mineral content loss, U.S. researchers found.

Researchers at Johns Hopkins University in Baltimore charted individual bone mineral content loss in men over an extended period and found a much larger decline in healthy men than in men later diagnosed with prostate cancer — especially those with high-risk prostate cancer.

“There are numerous possible mechanisms to explain the relationship between prostate cancer and bone mineral content” Dr. Stacy Loeb, the study’s lead author, said in a statement.

“Prostate cancer frequently spreads to bone and common growth factors might be involved in both bone maintenance and the progression of prostate cancer. We believe that this may be why the patients with the highest risk prostate cancer also demonstrated the least loss of bone mineral content as they got older, when compared with patients with non high-risk prostate cancer and no prostate cancer.”

Loeb and colleagues tracked 519 participants in the Baltimore Longitudinal Study — average age of 56 from 1973 to 1984 — for 22-35 years. Seventy-six men who took part in the study were diagnosed with prostate cancer, with just under one-quarter falling into the high-risk category.

The findings are published in the Journal of the British Association of Urological Surgeons.

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