Pre-emptive Prostate Pain Prevention Works

PHILADELPHIA, June 25 (UPI) — Providing pre-emptive pain relief to prostatectomy — removal of prostate — patients, U.S. researchers suggest.

Researchers at Thomas Jefferson University in Philadelphia found giving patients undergoing a robotic prostatectomy a multimodal pain relief regimen beginning before the procedure decreased the use of analgesics — as well as the number of side effects — in the long run.

The study, published in the journal Urology, found mean opioid dose, as measured in “total morphine equivalent dose,” was 75.3 mg for patients who received the standard regimen — versus 49.1 mg for patients receiving the pre-emptive multimodal regimen. The pre-emptive regimen patients did not report any additional side effects.

“This is the first demonstration of the effectiveness of a pre-emptive pain management protocol using pregabalin in urologic surgery,” Dr. Edouard J. Trabulsi said in a statement.

“We think this study paves the way for new pain management protocols.”

Trabulsi and colleagues conducted a retrospective study of 60 patients which studied 30 patients received a combination of drugs and 30 patients who had received only the standard postoperative analgesic regimen.

The pre-operative treatment included pregabalin — also known as Lyrica, acetaminophen and celecoxib given orally, two hours before the procedure and continued postoperatively in combination with intravenous ketorolac. The standard postoperative analgesic regimen included intravenous ketorolac, without pregabalin or celecoxib. All patients received oxycodone as needed.

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