Male Hormones Vital to Female Fertility

ROCHESTER, N.Y., May 28 (UPI) — A study in mice found male sex hormones might be key to optimal ovarian functioning, U.S. researchers said.

Researchers at New York’s University of Rochester Medical Center found male sex hormones — androgens — influenced ovulation in female mice.


The study, published in Molecular Endocrinology, found signaling by androgens in the ovaries of female mice regulated follicle growth — in particular the development and preservation of follicles containing growing eggs.

Lead author Aritro Sen and Dr. Stephen Hammes linked female infertility to signaling abnormalities due to irregular male hormone levels in the ovaries.

“Previously, we assumed that androgen signaling in the brain — the hypothalamus and the pituitary — was at the root of the problem, but we found that is not the case,” Sen said in a statement.

“The need for certain levels of male hormones in the female body and the strong influence these hormones have is often under appreciated — our findings open up a new line of research into how we can regulate male sex hormones, specifically in the ovaries, to improve fertility.”

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