Lack of REM Sleep Linked to Migraine

LOS ANGELES, June 23 (UPI) — U.S. researchers say being deprived of rapid eye movement sleep might play a role in migraine.

Researchers at Missouri State University’s Center for Biomedical & Life Sciences in Springfield, led by Paul Dunham, found sleep deprivation lead to changes in the levels of key proteins that in turn make possible events that may bring on migraine.


“We found that REM sleep deprivation caused increased expression of the proteins p38, PKA and P2X3, which are known to play an important role in initiating and sustaining chronic pain,” Dunham said in a statement.

Dunham and colleagues said they used a model of sleep deprivation and migraine established by previous clinical data and measured levels of proteins that lower the activation threshold of peripheral and central nerves involved in pain transmission during migraine.

The findings were reported at the American Headache Society’s 52nd annual scientific meeting in Los Angeles.

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