Estrogen Therapy Linked to Kidney Stones

DALLAS, Oct. 13 (UPI) — Estrogen therapy in post-menopausal women may increase the risk of developing kidney stones, U.S. researchers say.

Researchers at the University of Texas Southwestern Medical Center in Dallas find estrogen therapy after menopause increased a woman’s chances of developing kidney stones by approximately 20 percent. Estrogen therapy increased kidney stone risk irrespective of age, ethnicity, body mass index, prior hormone therapy use or use of coffee or thiazide diuretics.


Study lead author Dr. Naim Maalouf points out the study challenges the belief estrogen may protect against kidney stones.

“This research suggests that the opposite might be true, and it offers new information that might be considered when prescribing estrogen-replacement therapies to post-menopausal women,” Maalouf says in a statement.

The study, published in the Archives of Internal Medicine, also finds the development of kidney stones was five times more common in women who had a history of kidney stones prior to the trial.

Maalouf and colleagues conducted trials at 40 U.S. clinical centers where a total 10,739 post-menopausal women with hysterectomies and 16,608 post-menopausal women without hysterectomies were randomized to receive either an estrogen supplement or a placebo. Among those receiving hormones, 335 cases of kidney stones were reported versus 284 cases in the placebo groups.

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