Gene Linked with Cancer in Non-smokers

ROCHESTER, Minn., March 23 (UPI) — U.S. medical geneticists say they’ve linked a gene to lung cancer development in people called “never smokers.”

The study — co-led by the Mayo Clinic, Harvard University, the University of California-Los Angeles and the M.D. Anderson Cancer Center — found about 30 percent of never smoker patients who developed lung cancer had the same uncommon variant residing in a gene known as GPC5.


A never smoker is defined as a person who has smoked fewer than 100 cigarettes during his or her lifetime.

“This is the first gene that has been found that is specifically associated with lung cancer in people who have never smoked,” said Mayo Clinic genetic epidemiologist Dr. Ping Yang, who led the study.

The research teams scanned and analyzed the genomes of 2,272 participants who have never smoked, nearly 900 of whom were lung cancer patients. The scientists said it took them 12 years to identify and enroll the study participants.

“It has been very hard to do this research because never smokers have been mingled with smokers in past studies, and what usually pops up are genes related to nicotine dependence,” Yang said. “Findings from this study concern pure lung cancer that is not caused by smoking, and it gives us some wonderful new avenues to explore.”

The research appears in the early online edition of the journal Lancet Oncology.

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Categorized | Smoking
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