HAMILTON, Ontario, March 31 (UPI) — An anti-inflammatory drug may reduce inflammation symptoms with less incidence of bleeding often caused by other medications, Canadian researchers say.
John Wallace of the Farncombe Family Digestive Health Research Institute at McMaster University in Hamilton says animal models showed the drug ATB-346 — a derivative of naproxen that releases hydrogen sulfide, which may help protect the gastrointestinal tract — was at least as effective as naproxen in relieving inflammation and was 100 times safer than naproxen — with little or no damage to the stomach and small intestine.
The researchers said the drug helped the healing of pre-existing ulcers.
The research, published in the British Journal of Pharmacology, tested the drug on healthy rats, those with arthritis and inflammation, and on rats with compromised gastrointestinal tracts.
ATB-346 may also have less cardiovascular risk because — unlike naproxen — the researchers found no effects on blood pressure.
Naproxen, a non-steroidal anti-inflammatory drug such as Aleve, is commonly used for the reduction of intense pain, fever, inflammation and stiffness caused by conditions such as osteoarthritis, gout and other conditions.
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